Immunosuppression in idiopathic membranous nephropathy: A double-edge sword
نویسندگان
چکیده
منابع مشابه
Chapter 7: Idiopathic membranous nephropathy
BACKGROUND The diagnosis of MN is made on kidney biopsy. Diagnostic features include capillary wall thickening, normal cellularity, IgG and C3 along capillary walls on immunofluorescence, and subepithelial deposits on electron microscopy. MN is often seen in association with an underlying disorder (secondary MN). Secondary MN is more common in children (75%) than adults (25%) (Table 12). The di...
متن کاملTreatment of idiopathic membranous nephropathy.
Exciting progress recently has been made in our understanding of idiopathic membranous nephropathy, as well as treatment of this disease. Here, we review important advances regarding the pathogenesis of membranous nephropathy. We will also review the current approach to treatment and its limitations and will highlight new therapies that are currently being explored for this disease including Ri...
متن کاملHuman idiopathic membranous nephropathy--a mystery solved?
Just over 50 years ago, the late David Jones1 iden tified (using the periodic acid–Schiff and meth enamine silver stains) the unique glomerular pathologic features of membranous nephropathy, thus distinguishing it from other causes of “ne phrotic glomerulonephritis.” Subsequent immuno fluorescence and electronmicroscopical studies established that membranous nephropathy was also characteri...
متن کاملTreatment with rituximab in idiopathic membranous nephropathy
BACKGROUND Rituximab represents a valid therapeutic option to induce remission in patients with primary glomerulonephritis. Despite several studies proving its efficacy in improving outcomes in patients with membranous nephropathy (MN), its role in therapeutic protocols is not yet defined. METHODS We studied 38 patients with idiopathic MN treated with rituximab (in 13 patients as first-line t...
متن کاملImmunosuppression for progressive membranous nephropathy: a UK randomised controlled trial
BACKGROUND Membranous nephropathy leads to end-stage renal disease in more than 20% of patients. Although immunosuppressive therapy benefits some patients, trial evidence for the subset of patients with declining renal function is not available. We aimed to assess whether immunosuppression preserves renal function in patients with idiopathic membranous nephropathy with declining renal function....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Immunopathology and Pharmacology
سال: 2016
ISSN: 2058-7384,2058-7384
DOI: 10.1177/0394632016655170